Features of the course of COVID-19 in patients withsarcoidosis

Concomitant pathology is a risk factor for severe COVID-19. Bilateral changes characteristic of sarcoidosis onCTscan can also occur with coronavirus infection.The purpose of the study: based on our own data to study the features of the course of a new coronavirus infectionin patients with lung sarcoidosis.Materials and methods: 47 patients have been under observation which accounted for 22.4% of the total number ofobserved patients with sarcoidosis. Concomitant pathology: cardiovascular system - 24.9%, gastrointestinal tractpathology - 23.3%, COPD and bronchial asthma in 11.7%, diabetes mellitus in 5.25%. As a basic therapy, 74.5%received GCS, 5.2% - methotrexate, 16.2% - GCS +methotrexate. In addition, 32% took vitamin E and 19.8% -pentoxifylline.Results and discussion: The average age of patients is 37.2+/-3.4 (men 12, women 35). In 8 patients - pneumoniawas not detected;in 21 patients (CT stage 1) SpO2 95.2+/- 2.4%, in 15 patients (CT stage 2) SpO2 86.0+/- 4.5%, in 4patients (CT stage 3) COVID-19 had a severe SpO2 68.1+/- 7.3%, which required treatment in the intensive care unit. Blood parameters: IL-6 - 94.3+/-7.8 (N less than 3.4 ng/ml), CRP 103.4+/-8.9 (N 0-5 mg/L), ACE 82.3+/-7.3 (N 8-52 units/L), D-dimer 485+/-20.8 (N less than 442 ng/ml), ferritin 643.4+/-10.7 (N 28-365 ng/ml), GGT 104.5+/-3.7 (N 1-55 Units/L), procalcitonin 0.17 +/- 0.01 (N less than 0.1ng/ml). Conclusion(s): based on the data obtained, a severe course of COVID-19 was noted in 6.38% of patients with sarcoidosis, the course of moderate severity in 32%. The factors contributing to the severe course include the use of cytostatics and GCS.

Development of the Concept of a System for Registration of Biomarkers of Necrotic Changes and Lung Destruction in the Early Stages by Exhaled Air

The coronavirus-19 pandemic has shown that early diagnosis of structural changes in lung tissue is essential. However, many remote medical institutions lack the necessary equipment, such as a computed tomography scanner. In this work, we want to present the developed concept of a device that allows registering lung tissue abnormalities at early stages by detecting biomarkers in liquid droplets and human respiration. © 2022 IEEE.

Ferrous Metallurgy Production in Russia: How Will the COVID-19 Pandemic Affect?

Metallurgy is one of the key industries both in Russia and in the world. It has a significant influence on the situation in related industries. Therefore, the current state analysis of ferrous metallurgy production and its formation based on the short-term technological forecast is essential. Based on the foregoing, the research was aimed at analyzing the current state of ferrous metallurgy production in Russia and the impact of the COVID-19 pandemic on the prospects for industry development in the short term. The research studies the state of the ferrous metallurgy production in Russia and abroad before the COVID-19 pandemic, as well as the volume of industrial production in ferrous metallurgy and the industry structure. The COVID-19 pandemic has triggered a serious global recession, necessitating an analysis of the forecast for the development of the ferrous metallurgy industry. The research concludes that the Russian ferrous metals market is so far affected to a lesser extent compared to the European one.